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| Content Provider | IET Digital Library |
|---|---|
| Author | Godugu, Deepika Beedu, Sashidhar Rao |
| Abstract | The green synthesis of the platinum (Pt) nanocomposite was achieved using a natural biopolymer gum kondagogu (GK), a widely preferred reducing agent because of its biocompatible and biodegradable nature. The synthesised GK Pt nanoparticle (GKPtNP) were characterised by using different analytical techniques such as ultraviolet–visible spectrophotometer, transmission electron microscope, X-ray diffraction, and inductively coupled plasma mass spectroscopy (ICP-MS). The objective of the present work was to evaluate the anti-fungal activity of GKPtNP against two strains Aspergillus parasiticus and Aspergillus flavus for the first time. The results revealed that GKPtNP-treated fungal cell suspensions showed the minimum inhibitory concentration of 10 μg ml−1 for both the strains and exhibited IC50 values as 37.2 and 29.4 μg ml−1, against A. parasiticus and A. flavus. The mechanism of action of Pt nanocomposite on fungi outer membrane and generation of reactive oxygen species (ROS) was elucidated. It was observed that the interaction of GKPtNP caused destabilisation of fungal outer membrane signifying elevated levels of ROS leading to oxidative stress. In conclusion, the Pt nanocomposite materials acted as a fungicidal agent against A. parasiticus and A. flavus and give a significant scope in various biomedical applications. |
| Starting Page | 1491 |
| Ending Page | 1496 |
| Page Count | 6 |
| Volume Number | 13 |
| e-ISSN | 17500443 |
| Issue Number | Issue 10, Oct (2018) |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/mnl/13/10 |
| Alternate Webpage(s) | https://digital-library.theiet.org/content/journals/10.1049/mnl.2018.5097 |
| Journal | Micro & Nano Letters |
| Publisher Date | 2018-10-01 |
| Access Restriction | Open |
| Rights Holder | © The Institution of Engineering and Technology |
| Subject Keyword | Antibacterial Activity Antifungal Activity Aspergillus Flavus Aspergillus Parasiticus Biochemistry Biocompatible Nature Biodegradable Materials Biodegradable Nature Biomedical Material Cellular Biophysics Engineering Material Food Safety Fungal Outer Membrane Fungi Outer Membrane GKPtNP-treated Fungal Cell Suspensions Green Synthesis Health And Safety Aspects ICP-MS Industrial Processes Microorganisms Minimum Inhibitory Concentration Molecular Biophysics Nanocomposite Nanofabrication Nanoparticle Natural Biopolymer Gum Kondagogu Platinum Platinum Nanocomposite Product And Commodities Pt Nanocomposite Material Reactive Oxygen Species Reducing Agent Scanning Electron Microscopy Suspensions Synthesised GK Toxicology Transmission Electron Microscopy Ultraviolet Spectra Ultraviolet–visible Spectrophotometer Visible Spectra X-Ray Chemical Analysis X-Ray Diffraction |
| Content Type | Text |
| Resource Type | Article |
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