NDLI: Protein Function Prediction Based on Active Semi-supervised Learning

Content Provider	IET Digital Library
Author	Wang, Xuesong Cheng, Yuhu Li, Lijing
Abstract	In our study, the active learning and semisupervised learning methods are comprehensively used for label delivery of proteins with known functions in Proteinprotein interaction (PPI) network so as to predict the functions of unknown proteins. Because the real PPI network is generally observed with overlapping protein nodes with multiple functions, the mislabeling of overlapping protein may result in accumulation of prediction errors. For this reason, prior to executing the label delivery process of semi-supervised learning, the adjacency matrix is used to detect overlapping proteins. As the topological structure description of interactive relation between proteins, PPI network is observed with party hub protein nodes that play an important role, in co-expression with its neighborhood. Therefore, to reduce the manual labeling cost, party hub proteins most beneficial for improvement of prediction accuracy are selected for class labeling and the labeled party hub proteins are added into the labeled sample set for semisupervised learning later. As the experimental results of real yeast PPI network show, the proposed algorithm can achieve high prediction accuracy with few labeled samples.
Starting Page	595
Ending Page	600
Page Count	6
ISSN	10224653
Volume Number	25
e-ISSN	20755597
Issue Number	Issue 4, Jul (2016)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/cje/25/4
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/cje.2016.07.005
Journal	Chinese Journal of Electronics
Publisher Date	2016-07-01
Access Restriction	Open
Rights Holder	© Chinese Institute of Electronics
Subject Keyword	Active Semisupervised Learning Adjacency Matrix Biology And Medical Computing Biology Computing Biomolecular Interactions Charge Transfer Complexes Knowledge Engineering Technique Learning in AI Molecular Biophysics Overlapping Protein Node Party Hub Protein Node Protein Function Prediction Protein Label Delivery Protein-protein Interaction Network Proteins Topological Structure
Content Type	Text
Resource Type	Article
Subject	Applied Mathematics Electrical and Electronic Engineering

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