NDLI: Occurrence of HIV eradication for preexposure prophylaxis treatment with a deterministic HIV model

Content Provider	IET Digital Library
Author	Chang, Hyeygjeon Moog, Claude Astolfi, Alessandro
Abstract	The authors examine the human immunodeficiency virus (HIV) eradication in this study using a mathematical model and analyse the occurrence of virus eradication during the early stage of infection. To this end they use a deterministic HIV-infection model, modify it to describe the pharmacological dynamics of antiretroviral HIV drugs, and consider the clinical experimental results of preexposure prophylaxis HIV treatment. They also use numerical simulation to model the experimental scenario, thereby supporting the clinical results with a model-based explanation. The study results indicate that the protocol employed in the experiment can eradicate HIV in infected patients at the early stage of the infection.
Starting Page	237
Ending Page	243
Page Count	7
ISSN	17518849
Volume Number	10
e-ISSN	17518857
Issue Number	Issue 6, Dec (2016)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-syb/10/6
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-syb.2016.0008
Journal	IET Systems Biology
Publisher Date	2016-12-01
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Antiretroviral HIV Drug Deterministic HIV-infection Model Diseases Drugs Early Infection Stage HIV Eradication Human Immunodeficiency Virus Mathematical Model Numerical Analysis Numerical Approximation And Analysis Patient Care And Treatment Patient Treatment Pharmacological Dynamics Preexposure Prophylaxis HIV Treatment Virus Eradication
Content Type	Text
Resource Type	Article
Subject	Cell Biology Genetics Molecular Biology Modeling and Simulation Biotechnology

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