NDLI: Oscillatory expression in Escherichia coli mediated by microRNAs with transcriptional and translational time delays

Content Provider	IET Digital Library
Author	Zhang, Yuan Liu, Haihong Zhou, Jin
Abstract	The primary objective of this study is to study oscillatory expression of gene regulatory network in Escherichia coli mediated by microRNAs (sRNAs) with transcriptional and translational time delays. Motivated by the regulation of gene expression proposed by Shimoni et al. (Molecular Systems Biology, 2007), a general model of delayed gene regulatory network by sRNAs is formulated. This model can well describe many practical architectures of gene regulatory network by sRNAs, particularly when both transcriptional and translational time delays are introduced. Two functional issues on oscillatory expression of the gene regulatory network, i.e. stability and bifurcation, are investigated. Furthermore, an explicit algorithm determining the direction of Hopf bifurcation and stability of bifurcating periodic solutions is presented. It turns out that both transcriptional and translational time delays can induce gene expression in E. coli to be oscillatory even when its deterministic counterpart exhibits no oscillations. Moreover, the obtained results are in consistence with the experimental observations found in the biological literatures (Elowitz MB et al.: Nature, 2000, 403, pp. 335–338; Lennart Hilbert et al.: Mol. BioSyst, 2011, 7, pp. 2599–2607), which demonstrates that both transcriptional and translational time delays play an important role in the gene regulatory process of E. coli.
Starting Page	203
Ending Page	209
Page Count	7
ISSN	17518849
Volume Number	10
e-ISSN	17518857
Issue Number	Issue 6, Dec (2016)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-syb/10/6
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-syb.2016.0017
Journal	IET Systems Biology
Publisher Date	2016-12-01
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Bifurcation Biomolecular Interactions Biomolecular Structure, Configuration, Conformation, And Active Sites Charge Transfer Complexes Escherichia Coli Gene Regulatory Network Genetics Hopf Bifurcation Macromolecular Conformation (statistics And Dynamics) Microorganisms MicroRNAs Molecular Biophysics Nonlinear Dynamical System And Bifurcations Oscillatory Expression RNA Stability Transcriptional Time Delay Translational Time Delay
Content Type	Text
Resource Type	Article
Subject	Cell Biology Genetics Molecular Biology Modeling and Simulation Biotechnology

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