NDLI: Incorporation of ligand–receptor binding-site models and transistor-based sensors for resolving dissociation constants and number of binding sites

Content Provider	IET Digital Library
Author	Wang, Yu Lin Huang, Chih Cheng Kang, Yen Wen
Abstract	Ligand–receptor binding site model is used to elucidate the binding affinity between ligands and receptors, with transistor-based sensors. AlGaN/GaN high electron mobility transistors (HEMTs) were immobilised with antibodies and human immunodeficiency virus type 1 reverse transcriptase enzymes to detect peptides and human immunodeficiency virus drugs, respectively. The signals generated by the sensors because of the binding of the ligands to the receptors were fitted into the binding-site models and analysed. The dissociation constants of the ligand–receptor pairs and the number of the binding sites on the receptors were revealed. The results are very consistent with the data reported by the other methods from the literatures. The incorporation of the HEMTs and the binding-site models is demonstrated to be useful for studying the mechanism of the biomolecular interaction and the application for quick and cost-effective drug developments.
Starting Page	10
Ending Page	17
Page Count	8
ISSN	17518741
Volume Number	8
e-ISSN	1751875X
Issue Number	Issue 1, Mar (2014)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-nbt/8/1
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-nbt.2013.0031
Journal	IET Nanobiotechnology
Publisher Date	2014-03-04
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	AlGaN-GaN Aluminium Compound Antibodies Binding Affinity Biochemistry Biomolecular Interaction Biomolecular Interactions Biosensor Charge Transfer Complexes Cost-effective Drug Developments Decomposition Reactions (pyrolysis, Dissociation, And Group Ejection) Dissociation Dissociation Constants Drugs Enzymes Field Effect Device Gallium Compound HEMT High Electron Mobility Transistors Human Immunodeficiency Virus Drugs Human Immunodeficiency Virus Type 1 Reverse Transcriptase Enzymes III-V SemiConductor Ligand-receptor Binding Site Model Molecular Biophysics Peptides Physical Chemistry of Biomolecular Solutions And Condensed State Transistor-based Sonsor Wide Band Gap SemiConductor
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering Biotechnology

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