NDLI: Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling

Content Provider	IET Digital Library
Author	Lin, Hungyen Pei, Chunlei Markl, Daniel Shen, Yaochun Elliott, James A. Zeitler, J. Axel
Abstract	In recent years, terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here, we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method, it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis.
Starting Page	1775
Ending Page	1779
Page Count	5
ISSN	17518725
Volume Number	12
e-ISSN	17518733
Issue Number	Issue 11, Sep (2018)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/iet-map/12/11
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/iet-map.2018.5561
Journal	IET Microwaves, Antennas & Propagation
Publisher Date	2018-08-01
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Artificial Lab-scale Tablet Coating Process Coatings Cumulative Measurement Discrete Element Method Discrete Element Modelling Discrete Modelling Film Coating Thickness In-line Measurement Individual Pharmaceutical Tablets Industrial Processes Measurement Analysis Mixing Numerical Analysis Numerical Verification Off-line Measurement Pharmaceutical Industry Pharmaceuticals Product And Commodities Ray Tracing Semiconductor Technology Surface Treatment Tablet Mixing Tablet Pan Coater Terahertz In-line Measurement Modality Terahertz In-line Sensing
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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Impact of Processing Conditions on Inter-tablet Coating Thickness Variations Measured by Terahertz In-Line Sensing

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Development of a Process Analytical Technology (PAT) for in-line monitoring of film thickness and mass of coating materials during a pan coating operation

Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling

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Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling