NDLI: Fully integrated bio-chip with high sensitivity for electrochemical sensing application

Content Provider	IET Digital Library
Author	Chen, W. H. Chang, C. H. Shih, H. Y. Chiu, T. W. Kuo, C. N.
Abstract	This Letter presents a fully integrated bio-system with the property of high sensitivity for electrochemical detection, which can intrinsically measure electrochemical characteristics with cyclic voltammetry. In normal circumstances, ultra-low electrolytes exist in tissue solution, which is difficult to accurately detect the oxidation/reduction signals, limited by the innate circuit and liquid noise. Hence, the conventional topology of the potentiostat circuit is improved and proposed in this Letter to remove the required analogue-to-digital converter (ADC). The overall operational mechanism of the potentiostat behaves like a single-slope ADC, which achieves a compact, easily implemented, and low-noise design. Additionally, the effective capacitance of potentiostat and liquid resistance make an RC integration to further suppress out-of-band noise, thereby enabling the low-electrolyte detection and improving detecting sensitivity. To simulate the low-electrolyte environment, only 0.01 M (M = mol/l) phosphate buffered saline background solution is used and required to demonstrate its feasibility of the concept. The measured results show the sensor chip with high sensitivity to sense resistive variation of electrochemical action in low electrolytes.
Starting Page	438
Ending Page	440
Page Count	3
ISSN	00135194
Volume Number	55
e-ISSN	1350911X
Issue Number	Issue 8, Apr (2019)
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/el/55/8
Alternate Webpage(s)	https://digital-library.theiet.org/content/journals/10.1049/el.2018.6869
Journal	Electronics Letters
Publisher Date	2019-02-27
Access Restriction	Open
Rights Holder	© The Institution of Engineering and Technology
Subject Keyword	Analogue-to-digital Converter Chemical Analysis Chemical Sensor Chemical Variables Measurement Corrosion Cyclic Voltammetry Electrochemical Analytical Method Electrochemical Characteristic Electrochemical Detection Electrochemical Sensing Application Electrochemical Sensor Electrochemistry And Electrophoresis Electrolyte Etching Fully Integrated Biosystem Innate Circuit Liquid Noise Liquid Resistance Low-electrolyte Detection Environment Low-noise Design Other Surface Treatments Out-of-band Noise Suppression Oxidation Oxidation-reduction Signal Phosphate Buffered Saline Background Solution Potentiostat Circuit Topology RC Circuit RC Integration Single-slope ADC Tissue Solution Voltammetry
Content Type	Text
Resource Type	Article
Subject	Electrical and Electronic Engineering

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