NDLI: Pathway and Network Analysis of Schizophrenia Candidate Genes under Meta-Analysis Linkage Peaks

Content Provider	IEEE Xplore Digital Library
Author	Peilin Jia Jingchun Sun Leng Han Zhongming Zhao
Copyright Year	2009
Abstract	Schizophrenia is a major brain-related mental disorder. Many genes are likely associated with schizophrenia; their gene-gene interactions as well as gene-environment interactions may contribute as a major risk to the disorder. Rather than the traditional studies of single gene or marker, in this study we hypothesized that positional candidate genes under linkage peaks may play a major role in causing complex diseases such as schizophrenia through a mechanism of their gene-gene or protein-protein interactions. To test this hypothesis, we identified positional candidate genes under the linkage peaks from recently completed genome scan meta-analysis (GSMA) of the 32 genome-wide linkage studies. For these genes, we examined their enriched Gene Ontology (GO) annotations, identified significantly over-represented KEGG pathways, and, based on the genes in these pathways, extracted subnetworks from whole human protein-protein interaction network. Our results indicated that these schizophrenia candidate genes involve in important functions such as receptor activity, transcriptional regulation, neurobiological and signaling pathways, which support the neurotransmitter and neuroplasticity theories of schizophrenia. This study suggests that gene network and pathway is a powerful approach to uncovering the molecular mechanisms of complex diseases.
Starting Page	442
Ending Page	447
File Size	1142621
Page Count	6
File Format	PDF
ISBN	9780769537399
DOI	10.1109/IJCBS.2009.63
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-08-03
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Mental disorders Genomics Humans Ontologies gene network schizophrenia Diseases Couplings Proteins enriched pathway Neurotransmitters linkage meta-analysis candidate genes Bioinformatics Testing
Content Type	Text
Resource Type	Article

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