NDLI: Membrane protein biosensor arrays on CMOS

Content Provider	IEEE Xplore Digital Library
Author	Mason, A.J. Yue Huang
Copyright Year	2010
Description	Author affiliation: Michigan State University, East Lansing, MI USA (Mason, A.J.; Yue Huang)
Abstract	Membrane proteins play a vital role in biological function and have tremendous potential in microsystem array platforms utilizing bioelectrochemical methods for continuous use, label-free detection. To achieve this potential, challenges in membrane interfaces, on-CMOS electrode arrays, CMOS instrumentation electronics, and the integration of these technologies must be addressed. This paper outlines these challenges and summarizes recent developments toward membrane protein biosensor arrays on CMOS. A tethered bilayer lipid membrane with embedded alkali ion-channel protein is shown as example interface compatible with on-chip biosensor array realization. The development of on-CMOS electrode arrays and insulating layers capable of linking membrane protein interfaces with CMOS electronics is described. Finally, recent developments in CMOS instrumentation circuits for electrochemical impedance spectroscopy and multiple voltammetry measurements are presented. Together, these accomplishments demonstrate the viability of microsystem platforms utilizing membrane proteins.
Starting Page	212
Ending Page	218
File Size	1082855
Page Count	7
File Format	PDF
ISBN	9781424478095
e-ISBN	9781424478088
DOI	10.1109/ASQED.2010.5548245
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-08-03
Publisher Place	Malaysia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Protein engineering Insulation electrochemical impedance spectroscopy biosensor Instruments Circuits Lipidomics CMOS potentiostat Electrodes CMOS technology membrane protein Biomembranes Biosensors Joining processes
Content Type	Text
Resource Type	Article

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