NDLI: Chloroquine effect on human atrial action potential under normal conditions and during paroxysmal and chronic atrial fibrillation. A simulation study

Content Provider	IEEE Xplore Digital Library
Author	Duarte, M. Restrepo, A.L. Tobón, C. Cardona, K. Saiz, J.
Copyright Year	2013
Description	Author affiliation: I3BH, Univ. Politec. de Valencia, Valencia, Spain (Cardona, K.; Saiz, J.) \|\| GI2B, Inst. Tecnol. Metropolitano, Medellin, Colombia (Duarte, M.; Restrepo, A.L.; Tobón, C.)
Abstract	Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. If the paroxysmal AF (pAF) is not treated it could become chronic or permanent AF (cAF). Blockade of inward rectifying potassium $(I_{K1})$ and acetylcholine-activated potassium $(I_{KACh})$ currents by the antimalarial drug chloroquine could play a role as antiarrhythmic drug in human AF. We simulated the effects of chloroquine on human atrial cell and studied its effect on atrial action potential under normal conditions and during pAF and cAF. For this, we modified a human cell model to obtain pAF and cAF models, and we developed a model of chloroquine effects on $I_{K1}$ and $I_{KACh};$ this model fit well the experimental data. Our results show that chloroquine blocks both currents in a fraction greater as the concentration increases, prolonging its action in time, which results in an APD lengthening. Chloroquine has a greater effect on pAF conditions and high chloroquine concentration is needed to achieve similar effects in cAF. To our knowledge, this is the first work that has developed mathematical models of chloroquine effects on $I_{K1}$ and $I_{KACh}$ currents to study its effect on human atrial action potential.
Starting Page	1
Ending Page	5
File Size	597177
Page Count	5
File Format	PDF
ISBN	9781467362542
ISSN	2327817X
e-ISBN	9781467362573
DOI	10.1109/PAHCE.2013.6568230
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-04-29
Publisher Place	Colombia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Couplings chloroquine atrial fibrillation Conferences Atrial fibrillation mathematical models Action potential antiarrhythmic drugs Data models Mathematical model
Content Type	Text
Resource Type	Article

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