NDLI: Compact solid state pulsed power architecture for biomedical workflows: Modular topology, programmable pulse output and experimental validation on Ex vivo platelet activation

Content Provider	IEEE Xplore Digital Library
Author	Caiafa, A. Neculaes, V.B. Garner, A.L. Yan Jiang Klopman, S. Torres, A. LaPlante, N.
Copyright Year	2014
Description	Author affiliation: GE Global Res., Niskayuna, NY, USA (Caiafa, A.; Neculaes, V.B.; Yan Jiang; Klopman, S.; Torres, A.; LaPlante, N.) \|\| Sch. of Nucl. Eng., Purdue Univ., West Lafayette, IN, USA (Garner, A.L.)
Abstract	We describe a system based on a Marx generator approach using all solid state components in a modular topology that enables higher voltages by simply adding more modules. This novel system maximizes parameter flexibility, including electric pulse amplitude, duration and repetition rate. Example of pulses generated by this all solid state generator of ~20 kV/cm, ~ 600 ns pulse width, and more than 300 A per pulse are shown to activate platelets by stimulating human PRP (platelet rich plasma) in a 2 mm cuvette. Two growth factors released during platelet activation were identical whether nsPEFs (nanosecond pulsed electric fields) or bovine thrombin, the standard clinical platelet activator, was used. Future in vivo studies will assess the effectiveness of nsPEFs activated platelet gels compared to those activated by bovine thrombin.
Starting Page	35
Ending Page	40
File Size	315499
Page Count	6
File Format	PDF
ISBN	9781467373234
e-ISBN	9781479940479
DOI	10.1109/IPMHVC.2014.7287201
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-06-01
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	wound healing Bioelectrics Bovine Capacitors Generators Topology Blood platelets pulser design Biomembranes Plasmas electroporation solid-state
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
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