NDLI: Clonal Selection Algorithm with Aging Operators for Protein Structure Prediction on AB Off-Lattice Model

Content Provider	IEEE Xplore Digital Library
Author	Hongbing Zhu Jun Wu Chengdong Pu Xiaoli Lin Kei Eguchi Jinguang Gu
Copyright Year	2009
Abstract	Immune algorithms (IAs) are microscopic view of evolutionary algorithms (EAs) and applied in combinatorial optimization problems. This paper addresses to a clonal selection algorithm (CSA) that is one of the most representative IA and was applied into the protein structure prediction (PSP) on AB off-lattice model, in which the memory B cells of the CSA was innovated by employing different strategies: local search and global search in the phase of the mutation. And the CSA was further improved by adding aging operator to combat the premature convergence. However the pure aging operator didn’t achieve effective results and sometimes the optimum solution was eliminated. To resolve this problem, the current best solution was reserved by an antibody and it was not eliminated when its age reached its life span. In our experiments the improved algorithm was compared with the standard CSA and the pure aging CSA, which of the results demonstrated that the improved strategy with the memory B cells and long life aging was very effective to overcome premature convergence and to avoid trapped in the local-best solution, and it was also effective in keeping the diversity of the small size population.
Starting Page	685
Ending Page	688
File Size	169665
Page Count	4
File Format	PDF
ISBN	9781424455577
DOI	10.1109/ICINIS.2009.175
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-11-01
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Genetic mutations colnal selection algorithm Educational technology Predictive models Educational institutions Amino acids memory B cells Proteins Computer science Intelligent networks aging operators Aging AB Off-Lattice model Intelligent systems protein structure prediction Immune algorithms (IAs)
Content Type	Text
Resource Type	Article

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