NDLI: Robust Simulation for Decisional Problems Applied for Drug Testing

Content Provider	IEEE Xplore Digital Library
Author	Câmpean, Remus
Copyright Year	2008
Abstract	This paper is inspired from specific situations for the early phases of drugs testing. The particularity of the problem consists in the small dimension of the analyzed samples. For this reason, there is a presumption that the small dimension of samples affects the result of ANOVA statistical tests, when multiples groups have to be compared. Six dermatological treatments are tested on groups of ten patients each to test their effect on particular affections. In order to observe a difference between treatments an ANOVA technique is applied. The result suggests that no statistically significant difference can be observed between the six drugs. For objective reasons, despite the result of ANOVA, a hierarchy between drug’s variants must be established taking into account the general effect on the observed affections. The statistical inferential problem is converted into a decisional problem with weighted criteria of evaluation. The general decisional situation in which a set of alternatives are evaluated from the point of view of a set of criteria of evaluation is modeled and simulated. Then, the model is applied for the pharmaceutical problem. The robustness of the method of weighting the criteria of evaluation is studied using the empirical influence curve. Applying this method of ranking, one of the six creams is recommended as optimal with respect to all criteria of evaluation. The advantage of such an approach is that an inferential deadlock, due to the small number of data, can be surpassed. Computer implementations are made using Matlab.
Starting Page	117
Ending Page	121
File Size	382667
Page Count	5
File Format	PDF
ISBN	0769531148
DOI	10.1109/UKSIM.2008.51
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-04-01
Publisher Place	UK
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Computational modeling Computer simulation Medical simulation robustness ANOVA on small size samples dermopharmacy. Medical tests Robustness Mathematical model Analysis of variance simulation of a decisional situation Testing Pharmaceuticals
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Learning ANOVA concepts using simulation

Abim computer-based examination system

Position control of a small helicopter using robust backstepping

Analysis of communication network surveillance using functional ANOVA model with unequal variances

A LQG/LTR Based Robust Control Applied to a Steel Strip Coiling System

Robust controller design for automatic vehicle steering

Design of depth of anesthesia controllers in the presence of model uncertainty

On testing variance components in anova models.

Adaptive - Robust control a computational efficient real time simulation

Robust Simulation for Decisional Problems Applied for Drug Testing

Similar Documents

Learning ANOVA concepts using simulation

Abim computer-based examination system

Position control of a small helicopter using robust backstepping

Analysis of communication network surveillance using functional ANOVA model with unequal variances

A LQG/LTR Based Robust Control Applied to a Steel Strip Coiling System

Robust controller design for automatic vehicle steering

Design of depth of anesthesia controllers in the presence of model uncertainty

On testing variance components in anova models.

Adaptive - Robust control a computational efficient real time simulation

Robust Simulation for Decisional Problems Applied for Drug Testing