NDLI: Multiparametric MEMS biosensor for cell culture monitoring

Content Provider	IEEE Xplore Digital Library
Author	Fei Liu Nordin, A.N. Voiculescu, I.
Copyright Year	2013
Description	Author affiliation: Electr. & Comput. Eng. Dept., Int. Islamic Univ. Malaysia, Kuala Lumpur, Malaysia (Nordin, A.N.) \|\| Mech. Eng. Dept., City Coll. of New York, New York, NY, USA (Fei Liu; Voiculescu, I.) A novel micro-electro-mechanical (MEMS) multiparametric biosensor system based on living cells is presented. The biosensor system includes two biosensing techniques; resonant frequency measurements and electric cell-substrate impedance sensing (ECIS) on a single device. The multiparametric sensor system integrates uses the upper electrode of a quartz crystal microbalance (QCM) resonator and as working microelectrode for ECIS technique. The QCM consists of a thin AT-cut quartz substrate with two gold electrodes on opposite sides. Bovine aortic endothelial live cells (BAECs) were successfully cultured on this hybrid biosensor. The QCM upper gold electrode used for generating the acoustic wave is also used for ECIS measurements of the live cells. Gravimetric and impedimetric measurements were performed over a period of time on the same cell culture to validate the device's sensitivity. The time necessary for the cells to attach and form a compact monolayer is the same in the case of gravimetric and impedimetric measurements. This hybrid biosensor will be employed in the future for water toxicity detection.
Starting Page	1
Ending Page	5
File Size	310812
Page Count	5
File Format	PDF
ISBN	9781467344777
e-ISBN	9782355000263
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-04-16
Publisher Place	Spain
Access Restriction	Subscribed
Rights Holder	CMP
Subject Keyword	Electrodes thickness shear mode Resonant frequency bovine aortic endothelial cells quartz crystal microbalance resonant frequency Biosensors Impedance impedance spectroscopy measurements Biomedical monitoring Monitoring Acoustic waves
Content Type	Text
Resource Type	Article

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