NDLI: The influence of depression on deactivation and neural correlates during mental arithmetic tasks

Content Provider	IEEE Xplore Digital Library
Author	Shigang Feng Wei Wang Liang Chen Hongyu Fan Abraham, A. Jianlin Wu
Copyright Year	2013
Description	Author affiliation: Phys. Sci. & Tech. Coll., Dalian Univ., Dalian, China (Wei Wang) \|\| Affiliated Zhongshan Hosp., Dalian Univ., Dalian, China (Hongyu Fan; Jianlin Wu) \|\| Machine Intell. Res. Labs., Seattle, WA, USA (Abraham, A.) \|\| Sch. of Inf., Dalian Maritime Univ., Dalian, China (Shigang Feng; Liang Chen)
Abstract	Patients of depression often have lower performance in perception, planning, and execution in cognition, compared to healthy controls. Depression has been reported to be associated with functional alterations in the resting state connectivity in the brain. This study investigates whether there are differences in neural dynamics measured by mental arithmetic tasks (MAT) between depressed and healthy subjects. To this end, this study employed an ROI-based functional connectivity analysis, within-condition interregional covariance analysis (WICA), to explore the correlates of the brain deactivation regions. Results of this study showed that the corresponding emotional loop is inhibited in healthy subjects and show the control loops of attention and emotion is inhibited in depressed subjects during MAT, and the patients with depression may produce a stronger stress response than the healthy subjects during the MAT. This may be the key reason for that the mathematical abilities of the depression subjects were inferior to that of the healthy subjects.
Starting Page	359
Ending Page	363
File Size	651671
Page Count	5
File Format	PDF
e-ISBN	9781479935161
DOI	10.1109/ISDA.2013.6920701
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-12-08
Publisher Place	Malaysia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Within-condition interregional covariance analysis (WICA) Depression Biology Functional magnetic resonance imaging (fMRI) Mental arithmetic tasks (MAT)
Content Type	Text
Resource Type	Article

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