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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Orsi, G. De Maria, C. Vozzi, F. Guzzardi, M. Ahluwalia, A. Vozzi, G. |
| Copyright Year | 2009 |
| Abstract | Endothelial cells have central role in controlling blood vessels homeostasis, secreting vasodilator (Nitric Oxide, NO) and vasoconstrictor (Endothelin-1, ET-1) molecules, in response to various shear-stress levels due to blood flow. ENMET (Endothelial cell METabolism) is mathematical model that mimics completely the principal metabolic pathways in endothelial cell, connecting mechanical-stimuli responses (Et-1 and NO production) to main biochemical reactions. It is based on a set of non-linear differential equations, implemented in Simulink®, based on the cellular energetic state. The validation phase is based on experiments performed in a dynamic culture chamber where cell culture is exposed to a laminar flow that generates a well controlled shear stress. |
| Starting Page | 654 |
| Ending Page | 659 |
| File Size | 320627 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781424447350 |
| DOI | 10.1109/ISDA.2009.200 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2009-11-30 |
| Publisher Place | Italy |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Stress control Blood vessels Biochemistry Nitric Oxide Endothelial cells Centralized control Blood flow shear-stress Cells (biology) Production Differential equations Endothelin-1 mathematical model Mathematical model Joining processes |
| Content Type | Text |
| Resource Type | Article |
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