NDLI: Heparin regulates endothelin production through endothelium-derived nitric oxide in human endothelial cells.

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Heparin regulates endothelin production through endothelium-derived nitric oxide in human endothelial cells.

Content Provider	Semantic Scholar
Author	Yokokawa, Koji Tahara, Hideki Kohno, Masashi Mandal, Aloke K. Yanagisawa, Masashi Takeda, Tadanao
Copyright Year	1993
Abstract	Heparin shows blood pressure lowering effect in hypertensive patients and animal models. The present study examined the effect of heparin on vasoconstrictor endothelin-1 (ET-1) production in cultured human umbilical vein endothelial cells (ECs) to elucidate the mechanism of antihypertensive effect of heparin. Heparin suppressed both basal and thrombin-stimulated ET-1 mRNA expression paralleled with a decrease in ET-1 peptide release in a dose-dependent manner. Heparin concomitantly enhanced nitric oxide (NO) formation measured by NO2/NO3 levels and cGMP production in ECs. These enhancements were more marked when ECs were stimulated by thrombin. However, these heparin's effects were blunted in the presence of endothelium-derived nitric oxide (EDNO) synthesizing inhibitor NG-monomethyl L-arginine. Therefore, these results suggest that suppression of ET-1 production by heparin is EDNO mediated.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/116000/116805/JCI93116805.pdf
PubMed reference number	8408661v1
Volume Number	92
Issue Number	4
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Subject Keyword	Animal Model Antihypertensive Agents Arginine Cyclic GMP Endothelial Cells Endothelin Endothelin-1 Endothelium Hypertensive disease Nitric Oxide Patients Umbilical vein Umbilicus (Anatomy) Vasoconstrictor Agents heparin
Content Type	Text
Resource Type	Article

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