NDLI: Prediction of protein function by combining phylogenetic tree and mathematical inference

Content Provider	IEEE Xplore Digital Library
Author	Su-Ping Deng Jian Lu Wei Fu Ping Yu
Copyright Year	2014
Description	Author affiliation: West Anhui Univ., Luan, China (Su-Ping Deng; Ping Yu) \|\| Dept. of Comput. Technol. & Artistic Design, Jiangsu Vocational & Tech. Coll. of Finance & Econ., Huaian, China (Wei Fu) \|\| Coll. of Electron. & Inf. Eng., Tongji Univ., Shanghai, China (Jian Lu)
Abstract	Sequences lacking molecular function annotations have limited research value, so automated approaches for annotating molecular function are used to smooth over this deficiency. Whereas massive erroneous prediction results that may reduce the reliability and utility of these methods is non-ignorable in protein function prediction. Approaches combined phylogenomics and mathematical inference have been developed to label the proteins. However, real phylogenetic tree is always unknown and the prediction accuracies of the existing approaches need to be increased in practical applications. In order to take advantage of evolutionary information extracted from the protein sequences, we construct a phylogenetic tree based on the matrix that indicates the distance among different protein molecular sequences. Then an inference model was used to infer the specific molecular function of un-annotated proteins in phylogenetic tree. It generates more satisfactory results than the previous methods. The results show that it is a promising approach to predict the molecular function of proteins.
Starting Page	896
Ending Page	901
File Size	325547
Page Count	6
File Format	PDF
e-ISBN	9781479958382
DOI	10.1109/BMEI.2014.7002899
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-10-14
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Protein engineering Symmetric matrices Databases Phylogenetic tree Ontologies protein function Phylogeny Reliability Statistic inference
Content Type	Text
Resource Type	Article

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