NDLI: SLC- and NDUF-genes expression dynamics in pre-implantation embryonic development between bovine and mouse

Content Provider	IEEE Xplore Digital Library
Author	Knocker, L. Zheng Rong Yang
Copyright Year	2014
Description	Author affiliation: Sch. of Biosci., Univ. of Exeter, Exeter, UK (Knocker, L.; Zheng Rong Yang)
Abstract	Pre-implantation embryonic development (PED) is an important early process in life. Two issues are emerged for PED study. First, malfunction of PED can lead to future problems such as intrauterine growth retardation and diabetes. Second, PED conservation and diversity between species can be used to interpret genetics questions of human and animal health as well as environment protection. One of the best ways to PED study is to examine gene expressions during PED using high-throughput technology. Finding genes conserved in different species allows identification of genes that play key roles in PED, and helps explain the similar traits seen in embryos of diverse species. Furthermore, species-specific regulation of those conserved genes illustrates temporal differences in expressions, and therefore requirement of, essential proteins. Knowing these differences will help recognize the optimal requirements for growing different species embryos. We followed a previous study to use cross-species study approach to reveal the regulation pattern required for PED between mouse and bovine. Genes exhibiting significantly differential expressions between consecutive PED stages were detected for the mouse and bovine species. Among them, examined closely were genes encoding members of solute carrier proteins (slc-genes) and NADH dehydrogenase (ubiquinone) proteins (nduf-genes). The difference between mouse and bovine PED was found temporal. Some species-specific regulation of conserved genes representing disparity in utility of essential proteins during PED was also found in this study.
Starting Page	665
Ending Page	670
File Size	273153
Page Count	6
File Format	PDF
e-ISBN	9781479958382
DOI	10.1109/BMEI.2014.7002857
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-10-14
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Embryo Bovine Amino acids Mice Gene expression Probes
Content Type	Text
Resource Type	Article

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