NDLI: Detection of γ-aminobutyric acid level in vivo with MEGA-PRESS sequence at 1.5 Tesla

Content Provider	IEEE Xplore Digital Library
Author	Daiyue Zeng Zhiwei Shen Yeyu Xiao HaiYang Dai Renhua Wu Yaowen Chen
Copyright Year	2011
Description	Author affiliation: Engineering College of Shantou University, Shantou 515063, Guangdong, China (Daiyue Zeng; Yaowen Chen) \|\| Medical Imaging Department, The 2nd Affiliated Hospital of Shantou University, Shantou 515041, Guangdong, China (Zhiwei Shen; Yeyu Xiao; HaiYang Dai; Renhua Wu)
Abstract	γ-aminobutyric acid (GABA) is well-known for its low signal-to-noise ratio in vivo measurement with magnetic resonance spectrum (MRS) technique, especially detecting it at 1.5 Tesla scanners. The objective of this study is to achieve γ-aminobutyric acid concentration of cerebral regions with MEGA-PRESS sequence using a 1.5 T clinical MR scanner. MEAG-editing inserted into the point resolved spectroscopy sequence (PRESS) methods is a J-difference editing. It can detect weakly-coupled signals in GABA and make it visible by subtracting spectrums. In vivo experiments, a single voxel was located in the right Semiovale center of all four participates (two males, two females). MEGA-editing and nonrefocused spectrums were acquired separately by Edit-On/Off technique. The GABA peaks at 3.0 ppm were quite obviously seen, proving the favorable editing efficiency. jMRUI software 4.0 was applied to process the MR data and quantify the subtracted spectrum in the time domain. The vitro experiment was conducted as a standard to calculate the absolute concentration of GABA. The results indicated the feasibility of MEGA-PRESS sequence operating using 1.5 T scanners.
Starting Page	713
Ending Page	716
File Size	326349
Page Count	4
File Format	PDF
ISBN	9781424493517
e-ISBN	9781424493524
DOI	10.1109/BMEI.2011.6098488
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2011-10-15
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Couplings In vivo Spectroscopy Presses Humans γ-aminobutyric acid jMRUI Biomedical measurements MEGA-PRESS sequence Chemicals
Content Type	Text
Resource Type	Article

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