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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Yuzhi Liu Hailong An Suhua Zhang Junwei Li Yong Zhan |
| Copyright Year | 2011 |
| Description | Author affiliation: School of Electrical and Electronics Engineering, Shijiazhuang Tiedao University, 050043, Shijiazhuang, China (Yuzhi Liu) || School of Sciences, Hebei University of Technology, 300130, Tianjin, China (Hailong An; Suhua Zhang; Junwei Li; Yong Zhan) |
| Abstract | Potassium channels are exquisitely selective, allowing $K^{+}$ to cross cell membranes while blocking other ions, such as $Na^{+}$ and $Cs^{+}.$ It is now universally accepted that the selectivity filter is the functional unit that allows $K^{+}$ channels to distinguish potassium and sodium ions. In this paper, we adopted the density functional theory and the Brownian dynamics to study the selectivity mechanism of $KcsA^{D-Ala77}$ in low and high $[K^{+}]$ conditions. The results suggest that the extracelluar potassium ions can change the conformation of the ion channels which can affect the interaction between the ions and the filter of ion channels. It is the interaction that determines the selectivity of potassium ions channels. The $KcsA^{D-Ala77}$ can permeate potassium and sodium ions in low $[K^{+}]$ conditions, but only permeate potassium ions in high $[K^{+}]$ conditions. The results are consistent with the experimental data. The results may demonstrate that the selectivity is a property of the channel structure, not only the consensus sequence of amino. |
| Starting Page | 1844 |
| Ending Page | 1847 |
| File Size | 490326 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424493517 |
| e-ISBN | 9781424493524 |
| DOI | 10.1109/BMEI.2011.6098715 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-10-15 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Brownian dynamics Discrete Fourier transforms High K dielectric materials Ions Educational institutions Density functional theory Filtering theory Ion channels Selectivity Extracellular |
| Content Type | Text |
| Resource Type | Article |
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