NDLI: Research on risk assessment based on Monte Carlo simulation and dose-response multistage model

Content Provider	IEEE Xplore Digital Library
Author	Deyin Huang Mao Liu Jing Zhang Yang Wang
Copyright Year	2010
Description	Author affiliation: Research Center of Urban Public Safety, Nankai University, Tianjin 300071, China (Mao Liu; Jing Zhang; Yang Wang) \|\| Institute of Labor Hygeine, Tianjin Bohai Chemical Industry Group Co., 300051, China (Deyin Huang)
Abstract	The occupational hazard assessment of construction project implemented currently in China plays an important role in early prevention of occupational diseases. But the assessment techniques and methods are mostly based on qualitative mode or experience mode. There are still not unified and clear assessment methods and quantitative models to evaluate the chronic and potential cancer risk of chemicals. Because of the lack of scientific quantitative assessment methods, the risk can not be assessed quantitatively and scientifically. That also turns to be one of the technical difficulties demanding prompt solution in occupational hazards assessment. This paper introduced the risk assessment technique based on Monte Carlo simulation and dose-response multistage model. This method regarded the probabilistic risk of cancer as assessment target, and mainly used in quantitative assessment of cancer risk caused by chronic exposed to chemical carcinogens. The widely adopted four-step assessment method was used in health risk assessment, and it included hazard identification, dose-response assessment, exposure assessment and risk characterization. We used internal dose instead of external dose in assessment, and it made the result more accurate. The relationship between exposure dose and adverse health effect is determined by multistage model. For the uncertainty in exposure and risk assessment, we use Monte Carlo simulation to analyze the probability distribution. This method can be used practically in occupational hazards assessment and provide a scientific basis to the control of occupational hazards and the prevention and management of occupational tumor and other serious occupational diseases.
Starting Page	1245
Ending Page	1250
File Size	315687
Page Count	6
File Format	PDF
ISBN	9781424464951
e-ISBN	9781424464982
DOI	10.1109/BMEI.2010.5639276
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-10-16
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	risk assessment Monte Carlo methods dose-response model Biological system modeling Hazards occupational cancer Mathematical model Risk management workplace Chemicals Monte Carlo simulation Cancer
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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