NDLI: Signal processing for biologically inspired sensors

Content Provider	IEEE Xplore Digital Library
Author	Sattigeri, P. Thiagarajan, J.J. Ramamurthy, K.N. Konnanath, B. Mathew, T. Spanias, A. Goryll, M. Thornton, T. Prasad, S. Phillips, S.
Copyright Year	2010
Description	Author affiliation: SenSIP and CSSER Centers, School of ECEE, Arizona State University, Tempe, USA (Sattigeri, P.; Thiagarajan, J.J.; Ramamurthy, K.N.; Konnanath, B.; Mathew, T.; Spanias, A.; Goryll, M.; Thornton, T.; Prasad, S.; Phillips, S.)
Abstract	Pores or channels with diameters in the range of nanometers up to micrometers can be used as Coulter counting apertures to detect particles and organic molecules such as proteins. Coulter counting is performed by applying a constant potential across a nano- or micropore while recording the drop in ionic current upon passage of a molecule. Looking at the shape and duration of these current pulses enables us to estimate the size as well as the concentration of these molecules. Discrimination between different analytes can be performed by extracting appropriate features from the Coulter signals (events) and using them for classification. The challenge in being able to identify particular analytes is that a drop in current can also be caused by a molecule bouncing off the pore wall rather than moving through the micropore. Such drops are called non-events and can be discriminated from the events using Support Vector Machines. In this paper, we consider the amplitude of the current drop and the duration of the current pulse as features to determine if an event occurred. The proposed approach uses the Dirichlet process mixture model to cluster the data in the feature domain as the type of the events in the signal record is unknown. Results obtained show that the Dirichlet process mixture model accurately finds the types of events and their count for each signal record.
Starting Page	1
Ending Page	5
File Size	4063293
Page Count	5
File Format	PDF
ISBN	9781424462858
e-ISBN	9781424462872
DOI	10.1109/ISCCSP.2010.5463424
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-03-03
Publisher Place	Cyprus
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Wavelet transforms Shape Silicon pore Nanobioscience Clustering Proteins Signal processing Apertures Feature extraction Dirichlet process mixture model Performance analysis Biosensors Pulse shaping methods Signal analysis Biomedical signal processing
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in