NDLI: Detecting Functional Modules from Protein Interaction Networks

Content Provider	IEEE Xplore Digital Library
Author	Feng Luo Scheuermann, R.H.
Copyright Year	2006
Description	Author affiliation: Dept. of Comput. Sci., Clemson Univ., SC (Feng Luo)
Abstract	Accumulating evidence suggests that biological systems are composed of separable functional modules. Identifying these modules is essential in understanding the organization of biological systems. In this paper, we extend the indegree and outdegree concept of vertex to the sub-graph and propose a new formal definition of a module in a network. By combining our new network module definition with an adaptation of the Girvan-Newman algorithm, we propose a new divisive algorithm to detect modules from protein interaction networks. We applied our approach to the DIP yeast core protein interaction network and 81 compact simple modules with size larger than 3 are revealed. All 81 modules are significantly enriched for functional gene ontology terms. Comparison between our compact simple modules with the modules of Radicchi et al. showed that our modules are statistically more significant (lower P-value). Our approach provides a plausible way to identify functional modules within biological networks
Sponsorship	STEMES/IMSCCS Conference, USA The University of Iowa, USA Zhejing Univ., China Harbin Eng. Univ., China
Starting Page	123
Ending Page	130
File Size	460598
Page Count	8
File Format	PDF
ISBN	0769525814
DOI	10.1109/IMSCCS.2006.55
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-06-20
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins Computer science Fungi Pathology Finance Biological systems Ontologies Computer networks Large-scale systems Electronics packaging
Content Type	Text
Resource Type	Article

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