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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Ben-Qiong Hu Pei Shuai Zheng-chao Shan Chao-Yang Pang |
| Copyright Year | 2011 |
| Description | Author affiliation: Group of Gene Computation, College of Mathematics and Software Science, Sichuan Normal University, Chengdu, China (Pei Shuai; Zheng-chao Shan) || Group of Gene Computation, Key Lab. of Visual, Computation and Virtual Reality of Sichuan Province, Chengdu, China (Chao-Yang Pang) || College of Management Science, Chengdu University of Technology, Chengdu, China (Ben-Qiong Hu) |
| Abstract | Alzheimer's disease (AD) is the most ordinary kind of dementia. Identifying genes associated with AD is a new topic, and the key is to design algorithm to search AD genes. Gene order is a permutation of genes in which similar genes are ordered together. In this paper, a function is defined on gene order, and function value measures the similarity degree between a gene and its neighbors. Through the function value, the neighbors of a gene can be identified. The genes keeping as neighbor of AD gene (APOE, presenilins 1 or 2) at any stage (control, incipient, moderate, severe) are identified as the candidate of the gene associated with AD, where AD gene has been proved acting risk factor of AD. Experiment results of this paper have been proved some genes associated with AD. |
| Starting Page | 836 |
| Ending Page | 839 |
| File Size | 205371 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781457703720 |
| e-ISBN | 9781457703713 |
| DOI | 10.1109/GRC.2011.6122708 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-11-08 |
| Publisher Place | Taiwan |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | APOE (presenilins 1 or 2) Gene Expression Heating Alzheimer's Disease DNA Vectors Gene expression Alzheimer's disease Gene Order |
| Content Type | Text |
| Resource Type | Article |
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