NDLI: Identification of the differential DNA methylation markers among cancers

Content Provider	IEEE Xplore Digital Library
Author	Hongbo Liu Zhe Li Jing Ding Jie Liu Yan Zhang
Copyright Year	2013
Description	Author affiliation: Second Affiliated Hosp., Harbin Med. Univ., Harbin, China (Jing Ding; Jie Liu) \|\| Coll. of Pharmacy, Harbin Med. Univ., Harbin, China (Zhe Li) \|\| Coll. of Bioinf. Sci. & Technol., Harbin Med. Univ., Harbin, China (Hongbo Liu; Yan Zhang)
Abstract	DNA methylation plays important roles in the development of cancers. Previous studies have identified the differentially methylated sites (DMSs) between cancer and normal control. However, the methylation variations across multiple cancers have not been revealed. In this study, we identified DMSs among six human cancers (C-DMSs) and DMSs among five normal control tissues (T-DMSs). It is revealed that C-DMSs are highly overlapped with T-DMSs. By excluding the T-DMRs from C-DMRs, 4159 bona fide C-DMSs were selected as methylation variations across multiple cancers. Further analysis confirmed the roles of bona fide C-DMSs in regulation of cancer-related gene expression difference. Moreover, the genes related with these bona fide C-DMSs showed enrichment in the biological processes such as cell membrane components, cell adhesion, cell migration, immune response and cell proliferation, and also the pathways in cancer and bladder cancer. And twenty-eight genes are targeted by hsa-miR-323 which participates in tumorigenesis. In the end, we identified potential cancer-related genes by extracting protein interaction sub-network. This study provides a new framework for mining the potential cancer-specific methylation markers and oncogenes.
Sponsorship	IEEE Circuits Syst. Soc.
Starting Page	730
Ending Page	734
File Size	1162704
Page Count	5
File Format	PDF
ISBN	9781467352536
DOI	10.1109/FSKD.2013.6816291
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2013-07-23
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Proteins methylation variation ancer-specific methylation markers DNA Genomics DNA methylation bona fide C-DMSs Entropy Plasmas Bioinformatics Cancer
Content Type	Text
Resource Type	Article

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