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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Qiao Yongkang Li Bing Yan Yan Yang Xu |
| Copyright Year | 2007 |
| Description | Author affiliation: Lab. of Environ. Sci., Huazhong Normal Univ., Wuhan (Qiao Yongkang; Li Bing; Yan Yan; Yang Xu) |
| Abstract | To establish a method detecting the expression of vanilloid receptor type 1 (VR1) and explore the physiological role of VR1 as a possible bio-target molecule of formaldehyde (FA), $VR1^{+}-HEK293$ (human embryonic kidney, HEK) cell model was constructed using the VRl-cDNA plasmid through the molecular cloning and transfection technology. And then, testing of capsaicin and FA-induced cell death rate in transfected $VR1^{+}-$ HEK293 cells were carried out. The Results showed that VR1 was functionally expressed in $VR1^{+}-HEK293$ cell model, and measurement of $VR1^{+}-HEK293$ cell death rate should be an available and effective method, which can be applied in detecting the VR1 expression in cells in vitro; activated VR1 by FA could be blocked by capsazepine (CPZ), a specific antagonist of VR1, suggesting that VR1 may be the possible bio-target molecule of FA and related to the development of FA-induced airway irritant effect and neurogenic inflammation. |
| Starting Page | 98 |
| Ending Page | 101 |
| File Size | 415640 |
| Page Count | 4 |
| File Format | |
| ISBN | 1424411203 |
| DOI | 10.1109/ICBBE.2007.29 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2007-07-06 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Protocols Embryo Purification Humans Cloning DNA Cells (biology) Biochemistry In vitro Testing |
| Content Type | Text |
| Resource Type | Article |
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