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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Shao-Wu Zhang Quan Pan Yong-Mei Cheng Yun-Long Zhang Kuo-Chen Chou |
| Copyright Year | 2007 |
| Description | Author affiliation: Northwestern Polytech. Univ., Xian (Shao-Wu Zhang; Quan Pan; Yong-Mei Cheng) |
| Abstract | Evolutionary conservation estimated from a multiple sequence alignment is a powerful indicator of the functional significance of a residue, and helps to predict active sites, ligand binding sites, and protein interaction interfaces. Many algorithms that calculate conservation work well provided better and balanced alignment are used. Such a strong dependence on the alignment makes the results highly variable. Mihalek et al [1] introduced a class of hybrid methods to estimate the residue evolutionary conservation. Here, we propose an improved algorithm handling the gap in the multi-sequences alignment to compute the residue conservation scores. Comparing with Mihalek's and Ben -Tal's ConSurf methods, the results of simulation show that our methods are effective and increase the sensitivity and specificity of prediction, as well as make the conservation prediction algorithm more robust. |
| Starting Page | 80 |
| Ending Page | 83 |
| File Size | 197252 |
| Page Count | 4 |
| File Format | |
| ISBN | 1424411203 |
| DOI | 10.1109/ICBBE.2007.24 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2007-07-06 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Proteins Automation Databases Life estimation Sensitivity and specificity Educational institutions Amino acids Robustness Entropy Phylogeny |
| Content Type | Text |
| Resource Type | Article |
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