NDLI: Predicting distant metastasis in breast cancer using ensemble classifier based on context-specific miRNA regulation modules

Content Provider	IEEE Xplore Digital Library
Author	Xionghui Zhou Juan Liu Jianghui Xiong
Copyright Year	2012
Description	Author affiliation: Bioinformatics Group and Data Coordination Center, State Key Lab of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, P.R. China (Jianghui Xiong) \|\| School of Computer, Wuhan University, Wuhan, P.R. China (Xionghui Zhou; Juan Liu)
Abstract	Many methods based on building classifiers by selecting gene markers have been proposed to predict breast cancer patient's outcome However, most of them suffer from the problem of poor robustness, which are mainly due to the fact that the overlap degree of gene markers derived by different methods is not high, hading that few of them are generalized and can be widely used for clinical practice. In this paper, we present a method based on context-specific miRNA regulation modules to predict distant metastasis in breast cancer. First, we describe the regulation activity of a miRNA on a specific context by using CoMi (Context-specific miRNA activity) score, based on which, several miRNAs regulate on the same context are regarded as a miRNA regulation module; then the discriminate regulation modules are selected and each is used to construct a classification model separately; finally, an ensemble classifier is established by combining all the models with a majority voting strategy. The evaluation experiment results show that our method performs better than previous works. In addition, the obtained discriminate modules show great stability across different data sets (withp-value of 1.119e-06).
Starting Page	1
Ending Page	6
File Size	1903784
Page Count	6
File Format	PDF
ISBN	9781467325592
e-ISBN	9781467325608
e-ISBN	9781467325585
DOI	10.1109/BIBM.2012.6392717
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-04
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Context Cancer prognosis Breast cancer Robustness ensemble classifier Metastasis miRNA regulation network Tumors context specific miRNA activity
Content Type	Text
Resource Type	Article

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