NDLI: Using gene sets to identify putative drugs for breast cancer

Content Provider	IEEE Xplore Digital Library
Author	Tzu-Hung Hsiao Chen, H.H. Yidong Chen Yu-Heng Chen Chuang, E.Y.
Copyright Year	2012
Description	Author affiliation: Graduate Institute of Biomedicai Electronics and Bioinfomatics, National Taiwan University, Taiwan (Yu-Heng Chen; Chuang, E.Y.) \|\| Greehey Children's Cancer Research Institute, University of Texas Health Science Center at San, Antonio, San Antonio, Texas (Tzu-Hung Hsiao; Chen, H.H.; Yidong Chen)
Abstract	The number of current anti-cancer drugs was limited and the response rates were also not high. To "reposition" known drugs as anti-cancer drugs to increase the therapeutic efficiency, we presented a novel analysis framework to identify putative drugs for cancer. Using breast cancer as example, a "cancer — gene sets — drugs" network was constructed through two procedures. First, the "gene sets — drugs" network was built by applying the expression pattern of drugs for gene set enrichment analysis. Secondly, the breast cancer progression associated gene sets were identified by survival analysis of patient cohorts. By integrating the two results, 25 tumor progression associated gene sets and 360 putative anti-cancer drugs were identified. Our method has the ability to identify the "reposition" drugs and the potential affected mechanisms of tumor progression concurrently. It will be useful to speed up the development of anti-cancer drugs from bench to clinical application.
Starting Page	1
Ending Page	4
File Size	2326078
Page Count	4
File Format	PDF
ISBN	9781467325592
e-ISBN	9781467325608
e-ISBN	9781467325585
DOI	10.1109/BIBM.2012.6392616
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-10-04
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Inhibitors gene set breast cancer Breast cancer Hazards Tumors Diseases drug
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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