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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Gosal, G.P.S. Kannan, N. Kochut, K.J. |
| Copyright Year | 2011 |
| Abstract | Protein kinases play a prominent role in cell regulation and disease, which has given rise to an abundance of information about the structure, function, disease, pathway, interaction and evolution of these proteins. This information, however, is currently spread across several heterogeneous resources, an obstacle to the kind of integrative approaches needed in utilizing existing knowledge for research related to diseases. We have designed and developed an ontology for protein kinases, ProKinO, that serves as a useful and efficient representation of the integrated knowledge about these complex proteins which are intimately involved in the genesis and behavior of cancer cells. Concepts and relationships in ProKinO capture important knowledge about kinases while ProKinO instances represent a wealth of data acquired from disparate resources, including Kin Base, COSMIC, UniProt, and Reactome. We have created a customized ontology browser for ProKinO. Also, we used ProKinO to do a variety of integrative analyses using SPARQL queries. |
| Starting Page | 550 |
| Ending Page | 555 |
| File Size | 783449 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781457717994 |
| DOI | 10.1109/BIBM.2011.125 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-11-12 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Proteins Protein engineering Databases OWL Ontologies automatic population protein kinases integrative analysis Browsers ontology Diseases Cancer |
| Content Type | Text |
| Resource Type | Article |
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