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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Jun Kong Lee, M.J. Bagci, P. Sharma, P. Martin, D. Adsay, N.V. Saltz, J.H. Farris, A.B. |
| Copyright Year | 2011 |
| Abstract | Most pathology analyses and measurements are prevalently carried out by trained reviewers in both clinical and research settings. Therefore, the resulting outputs are inexorably biased by interpreters and degraded with poor reproducibility. In this paper, we propose a computerized image analysis paradigm enabling quantitative characterizations of steatosis areas in microscopy images of pediatric liver biopsies. With the same set of patients, we also acquired the lipid measurements from magnetic resonance imaging data analysis for correlation investigation. Our preliminary results suggest a high correlation between the steatosis areas quantized with microscopy images and the lipid percentages calculated from radiology imaging data. Additionally, we compared the performance of the proposed analysis method with those of three certified pathologists and a popular commercial algorithm. The results suggest the superiority of our method to both human reviewers and the commercial method in terms of the steatosis-lipid correlation strength. This demonstrates that the developed method is promising for generating quantitative and reliable analysis results to better support further liver disease study. |
| Starting Page | 333 |
| Ending Page | 338 |
| File Size | 899026 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781457717994 |
| DOI | 10.1109/BIBM.2011.37 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2011-11-12 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Image segmentation Correlation Large-scale microscopy image analysis Shape Microscopy Liver Radiology Liver steatosis quantification Tissue representation Lipidomics Parallel computation Data correlation |
| Content Type | Text |
| Resource Type | Article |
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