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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Bo Xu Hongfei Lin Zhihao Yang |
| Copyright Year | 2010 |
| Description | Author affiliation: Department of Computer Science and Engineering, Dalian University of Technology, Dalian, China (Bo Xu; Hongfei Lin; Zhihao Yang) |
| Abstract | Protein complexes can be identified from the protein interaction networks derived from experimental data sets. However, these analyses are challenging because of the presence of unreliable interactions and the complex connectivity of the network. The integration of protein-protein interactions with the data from other sources can be leveraged for improving the effectiveness of protein complexes detection algorithms. We have developed novel semantic similarity method, which use Gene Ontology (GO) annotations to measure the reliability of protein-protein interactions. The protein interaction networks can be converted into a weighted graph representation by assigning the reliability values to each interaction as a weight. Following the approach of previously proposed clustering algorithm IPCA which expands clusters starting from seeded vertices, we present a clustering algorithm OIIP based on the new weighted Protein-Protein interaction networks for identifying protein complexes. The algorithm OIIP is applied to the protein interaction network of Sacchromyces cerevisiae and identifies many well known complexes. Experimental results show that the algorithm OIIP has higher F-measure and accuracy compared to other competing approaches. |
| Starting Page | 290 |
| Ending Page | 295 |
| File Size | 470567 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781424483068 |
| e-ISBN | 9781424483075 |
| DOI | 10.1109/BIBM.2010.5706579 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-12-18 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Proteins Protein engineering Protein complex Accuracy Clustering algorithms Tin PPI networks Bioinformatics Gene Ontology |
| Content Type | Text |
| Resource Type | Article |
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