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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Yang Liu Yiu Fai Lee Ng, M.K. |
| Copyright Year | 2010 |
| Description | Author affiliation: Department of Mathematics, Hong Kong Baptist University, Kowloon Tong, Hong Kong (Yang Liu; Yiu Fai Lee) || Centre for Mathematical Imaging and Vision, Hong Kong Baptist University, Kowloon Tong, Hong Kong (Ng, M.K.) |
| Abstract | Detection of genomic DNA copy number variations (CNVs) can provide a complete and more comprehensive view of human disease. In this paper, we incorporate DNA copy number variation data derived from SNP arrays into a computational shrunken model and formalize the detection of copy number variations as a case-control classification problem. By shrinkage, the number of relevant CNVs to disease can be determined. In order to understand relevant CNVs, we study their corresponding SNPs in the genome and find out the unique genes that those SNPs are located in. A gene-gene similarity value is computed using GOSemSim and gene pairs that has a similarity value being greater than a threshold are selected to construct several groups of genes. For the SNPs that involved in these groups of genes, a statistical software PLINK is employed to compute the pair-wise SNP-SNP interactions, and identify SNP networks based on their p-values. By using two real genome-wide data sets, we further demonstrate SNP and gene networks play a role in the biological process. An analysis shows that such networks have relationships directly or indirectly to disease study. |
| Starting Page | 9 |
| Ending Page | 12 |
| File Size | 435407 |
| Page Count | 4 |
| File Format | |
| ISBN | 9781424483068 |
| e-ISBN | 9781424483075 |
| DOI | 10.1109/BIBM.2010.5706526 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2010-12-18 |
| Publisher Place | China |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | shrunken single nucleotide polymorphism Genomics Humans networks classification Diseases Accuracy genome-wide copy number variation Diabetes Arrays Bioinformatics |
| Content Type | Text |
| Resource Type | Article |
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