NDLI: Metabolic pathway complements of eight Escherichia coli strains

Content Provider	IEEE Xplore Digital Library
Author	Farber, C. Neary, J.L. Lilburn, T.G. Yufeng Wang
Copyright Year	2008
Description	Author affiliation: Univ. of Texas at San Antonio, San Antonio, TX (Farber, C.; Neary, J.L.; Yufeng Wang) \|\| American Type Culture Collection, Manassas, VA (Lilburn, T.G.)
Abstract	We examined the metabolic capabilities of eight Escherichia coli strains in order to identify variations among these strains which might account for their alternate mechanisms of infection or levels of virulence. Our data set included two non-pathogenic strains, two diarrheagenic strains and four extra-intestinal pathogenic strains. The metabolic pathway complements of these strains were deduced using the Pathway Tools software. The results were hand-corrected using the NCBI database, EcoCyc, and tBLASTn. After curation, only 20 differences were discerned among the strains, but a few of these differences are intriguing. Two of the pathways are involved in the biosynthesis of lipopolysaccharides, which are known virulence determinants. Further research is needed to test the implications of our findings, but this study has identified possible metabolic variations that may prove significant for understanding the pathogenicity of different E. coli strains.
Starting Page	127
Ending Page	131
File Size	85521
Page Count	5
File Format	PDF
ISBN	9781424428908
DOI	10.1109/BIBMW.2008.4686225
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2008-11-03
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Pathogens Databases Humans Genomics Capacitive sensors Organisms Bioinformatics Software tools Diseases Testing
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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