NDLI: Online individualized dose estimation

Content Provider	IEEE Xplore Digital Library
Author	Rocha, C. Mendonca, T. Silva, M.E.
Copyright Year	2009
Description	Author affiliation: Faculdade de Ciências Universidade do Porto Rua Campo Alegre 687, 4169-007, Portugal (Rocha, C.; Mendonca, T.) \|\| Faculdade de Economia Universidade do Porto Rua Dr. Roberto Frias, 4200-464, Portugal (Silva, M.E.)
Abstract	The development of automated individualized drug dosage regimens, namely in general anaesthesia environment, has been a subject of interest in the last decades. The use of continuous intravenous drug administration aims at, accurately, maintaining the system at a desired target effect concentration level. Different methods have been proposed for the design of individualized dosage regimens. In this study individual drug dose design is achieved through the characterization of transient initial response induced by a bolus administration of drug. This approach is based on the statistical analysis of the data using Walsh-Fourier spectral analysis which provides information about patient dynamics, allowing the on-line drug dose design using multiple linear least squares and quantile regression technics. The proposed methodology is illustrated in the case where the effect measured on the patient corresponds to the neuromuscular blockade (NMB) level and the drug to the muscle relaxant atracurium.
Starting Page	275
Ending Page	279
File Size	317150
Page Count	5
File Format	PDF
ISBN	9781424450572
DOI	10.1109/WISP.2009.5286553
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-08-26
Publisher Place	Hungary
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drugs Statistical analysis Neuromuscular Pharmaceutical technology Muscles Robustness Biomedical measurements Least squares methods Spectral analysis Biomedical signal processing
Content Type	Text
Resource Type	Article

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