NDLI: Subretinal implants for the recovery of vision

Content Provider	IEEE Xplore Digital Library
Author	Schubert, M.B. Stelzle, M. Graf, M. Stert, A. Nisch, W. Graf, H.G. Hammerle, H. Gabel, V.P. Hofflinger, B. Zrenner, E.
Copyright Year	1999
Description	Author affiliation: Inst. for Phys. Electron., Stuttgart Univ., Germany (Schubert, M.B.)
Abstract	The German 'SubRet' consortium has fabricated various types of microphotodiode arrays, the photovoltaic response of which will induce a retina response after implantation in the subretinal space. Ultrathin and flexible devices have been designed as well as CMOS-based chips with different pixel sizes and electrode configurations. From in-vitro electrostimulation studies, it becomes clear that a purely photovoltaic mode of operation will not be feasible, but an additional energy input by near-infrared radiation or radio frequency power transmission needs to be incorporated. Implantation experiments on pigs and rabbits prove the biocompatibility, general function and local stability of the implants. The inner retina architecture is well preserved, and literally no glia proliferation is found from long-term monitoring and histological examination. In conclusion, the subretinal approach is very promising and our results are encouraging, although major obstacles cannot be excluded concerning the application in human.
Starting Page	376
Ending Page	381
File Size	882766
Page Count	6
File Format	PDF
ISBN	0780357310
ISSN	1062922X
DOI	10.1109/ICSMC.1999.812431
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1999-10-12
Publisher Place	Japan
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Implants Photovoltaic systems Solar power generation Retina Electrodes In vitro Radio frequency Power transmission Rabbits Stability
Content Type	Text
Resource Type	Article

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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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