NDLI: Integrated PDMS/CMOS Microsystem for Autonomous Incubation and Imaging in Cell Culture Studies

Content Provider	IEEE Xplore Digital Library
Author	Blain Christen, J.M. Andreou, A.G.
Copyright Year	2006
Description	Author affiliation: Dept. of Electr. Eng., Johns Hopkins Univ., Baltimore, MD (Blain Christen, J.M.; Andreou, A.G.)
Abstract	We discuss the design, fabrication and testing of a hybrid microsystem for stand-alone cell culture, incubation and imaging. The micro-incubator is engineered through the integration of two CMOS dies. The first for the heater and temperature sensor, and a second die for imaging. A multilayer PDMS (polydimethylsiloxane) structures is used to create not only the fluidic structures but to encapsulate the CMOS dies. The microfluidic features include fluidic channels, a 4 mm diameter, 30muL, culture well and a 25 micron thick PDMS membrane that covers the top of the culture well, acting as barrier to contaminants while allowing the cells to exchange gases with the ambient environment. The micro-incubator interface includes with a flexible polyimide ribbon cable and four fluidic ports. The complete structure has a size of (2.5times2.5times0.6 $cm^{3}).$ We have employed the device to successfully culture BHK-21 cells autonomously over a sixty hour period in ambient environment
Starting Page	1
Ending Page	2
File Size	2733982
Page Count	2
File Format	PDF
ISBN	1424402778
DOI	10.1109/LSSA.2006.250430
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2006-07-13
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	CMOS image sensors Microfluidics Fabrication Testing Temperature sensors Nonhomogeneous media Fluidic microsystems Biomembranes Gases Polyimides
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Design, Fabrication, and Testing of a Hybrid CMOS/PDMS Microsystem for Cell Culture and Incubation

Hybrid silicon/silicone (polydimethylsiloxane) microsystem for cell culture

Hybrid Silicon/Silicone (polydimethylsiloxane) Microsystem for Cell Culture

Design, Fabrication and Testing of a Hybrid CMOS/PDMS Microsystem for Cell Culture and Incubation

Micro fluidic single embryo culture systems in PDMS

A water spectroscopy microsystem with integrated discharge source, dispersion optics, and sample delivery

A Bistable Pneumatic Microswitch For Driving Fluidic Components

Microthermopiles integrated with fluidic channels as calorimetric MEMS biosensors

Fluidic micromixer made in LTCC technology - preliminary results

Integrated PDMS/CMOS Microsystem for Autonomous Incubation and Imaging in Cell Culture Studies

Similar Documents

Design, Fabrication, and Testing of a Hybrid CMOS/PDMS Microsystem for Cell Culture and Incubation

Hybrid silicon/silicone (polydimethylsiloxane) microsystem for cell culture

Hybrid Silicon/Silicone (polydimethylsiloxane) Microsystem for Cell Culture

Design, Fabrication and Testing of a Hybrid CMOS/PDMS Microsystem for Cell Culture and Incubation

Micro fluidic single embryo culture systems in PDMS

A water spectroscopy microsystem with integrated discharge source, dispersion optics, and sample delivery

A Bistable Pneumatic Microswitch For Driving Fluidic Components

Microthermopiles integrated with fluidic channels as calorimetric MEMS biosensors

Fluidic micromixer made in LTCC technology - preliminary results

Integrated PDMS/CMOS Microsystem for Autonomous Incubation and Imaging in Cell Culture Studies