Please wait, while we are loading the content...
| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Felekis, D. Weber, A. Muntwyler, S. Routier-Kierzkowska, A. Beyeler, F. Smith, R.S. Nelson, B.J. |
| Copyright Year | 2012 |
| Description | Author affiliation: Institute of Robotics and Intelligent Systems, ETH Zurich, 8092, Switzerland (Felekis, D.; Weber, A.; Muntwyler, S.; Routier-Kierzkowska, A.; Beyeler, F.; Smith, R.S.; Nelson, B.J.) |
| Abstract | Understanding the process of cellular morphogenesis requires the characterization of local mechanical properties of living cells in situ. For this purpose, an automated microrobotic system, the Cellular Force Microscope (CFM) has been developed. Its suitability for single cell characterization has been reported in previous work and extensive use on characterization of both single cells and tissues has been demonstrated. A simple experimental method for the determination of the CFM's accuracy, based on the comparison of the measured stiffness with the true stiffness of a calibrated SI-traceable reference artifact, is demonstrated. This method is a practical alternative to the complex complete uncertainty analysis of all the sensors involved in the stiffness measurement based on an SI-traceable reference artifact. We then use the CFM to characterize the stiffness of living Tobacco BY2 cells. The apparent stiffness is determined from the force indentation curves collected from living cells at forces ranging from 10 microNewtons to forces in which the cell slips away or ruptures. The results show a nonlinear increase in the apparent cell stiffness as the applied load increases. This observation combined with the reference measurements done on the calibrated stiffness standard dictate that the stiffness variation stems from the biological organism and not from the CFM. |
| Starting Page | 285 |
| Ending Page | 290 |
| File Size | 497979 |
| Page Count | 6 |
| File Format | |
| ISBN | 9781467304290 |
| ISSN | 21618070 |
| e-ISBN | 9781467304306 |
| DOI | 10.1109/CoASE.2012.6386345 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2012-08-20 |
| Publisher Place | Korea (South) |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Force Force measurement Sensors Accuracy Measurement uncertainty Uncertainty Position measurement |
| Content Type | Text |
| Resource Type | Article |
National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.
Learn more about this project from here.
NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.
Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.
| Sl. | Authority | Responsibilities | Communication Details |
|---|---|---|---|
| 1 | Ministry of Education (GoI), Department of Higher Education |
Sanctioning Authority | https://www.education.gov.in/ict-initiatives |
| 2 | Indian Institute of Technology Kharagpur | Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project | https://www.iitkgp.ac.in |
| 3 | National Digital Library of India Office, Indian Institute of Technology Kharagpur | The administrative and infrastructural headquarters of the project | Dr. B. Sutradhar bsutra@ndl.gov.in |
| 4 | Project PI / Joint PI | Principal Investigator and Joint Principal Investigators of the project |
Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon |
| 5 | Website/Portal (Helpdesk) | Queries regarding NDLI and its services | support@ndl.gov.in |
| 6 | Contents and Copyright Issues | Queries related to content curation and copyright issues | content@ndl.gov.in |
| 7 | National Digital Library of India Club (NDLI Club) | Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach | clubsupport@ndl.gov.in |
| 8 | Digital Preservation Centre (DPC) | Assistance with digitizing and archiving copyright-free printed books | dpc@ndl.gov.in |
| 9 | IDR Setup or Support | Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops | idr@ndl.gov.in |
|
Loading...
|