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| Content Provider | IEEE Xplore Digital Library |
|---|---|
| Author | Ramamohan, Varun Abbott, James T. Yih, Yuehwern |
| Copyright Year | 2014 |
| Description | Author affiliation: Roche Diagnostics Corporation, 9115 Hague Road, PO Box 50457, Indianapolis, IN 46250-0457, USA (Abbott, James T.) || Research Triangle Institute - Health Solutions, 300 Park Offices Drive, Durham, NC 27703, USA (Ramamohan, Varun) || School of Industrial Engineering, Purdue University, West Lafayette, IN 47907, USA (Yih, Yuehwern) |
| Abstract | Results of clinical laboratory tests inform every stage of the medical decision-making process, and measurement of enzymes such as alanine aminotransferase provide vital information regarding the function of organ systems such as the liver and gastrointestinal tract. Estimates of measurement uncertainty quantify the quality of the measurement process, and therefore, methods to improve the quality of the measurement process require minimizing assay uncertainty. To accomplish this, we develop a physics-based mathematical model of the alanine aminotransferase assay, with uncertainty introduced into its parameters that represent variation in the measurement process, and then use the Monte Carlo method to quantify the uncertainty associated with the model of the measurement process. Furthermore, the simulation model is used to estimate the contribution of individual sources of uncertainty as well as that of uncertainty in the calibration process to the net measurement uncertainty. |
| Starting Page | 1329 |
| Ending Page | 1340 |
| File Size | 207974 |
| Page Count | 12 |
| File Format | |
| e-ISBN | 9781479974863 |
| DOI | 10.1109/WSC.2014.7019988 |
| Language | English |
| Publisher | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Publisher Date | 2014-12-07 |
| Publisher Place | USA |
| Access Restriction | Subscribed |
| Rights Holder | Institute of Electrical and Electronics Engineers, Inc. (IEEE) |
| Subject Keyword | Uncertainty Measurement uncertainty Biochemistry Mathematical model Calibration Optical variables measurement Instruments |
| Content Type | Text |
| Resource Type | Article |
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