NDLI: Bioanalytical silicon micro-devices for DNA

Content Provider	IEEE Xplore Digital Library
Author	Simion, M. Kleps, I. Ignat, T. Condac, E. Craciunoiu, F. Angelescu, A. Miu, M. Bragaru, A. Costache, M. Savu, L.
Copyright Year	2005
Description	Author affiliation: National Inst. for R&D in Microtechnol., Bucharest, Romania (Simion, M.; Kleps, I.; Ignat, T.)
Abstract	In this paper, we focus on the design, the experimental technology and characterization of a silicon microchip for rapid testing of DNA samples. For the identification it was used a polymerase chain-reaction PCR technique with biomolecules attached. In the last year, there have been a number of recent advances in the field of miniaturized reaction and separation systems, including the construction of fully integrated "lab-on-chip" systems. This paper describes a micro biochip realized on silicon wafers, using standard microfabrication techniques. The biochip is designed to be complex and versatile; it contains a microreactor for the biological material and on the backside of the chip there are heating resistances that would assure the temperature cycles for PCR reactions. The biologic material in the test reactors can be optically monitored because the reactor is covered with transparent glass. The reactor surface was functionalized in order to obtain reactive sites for binding DNA-oligonucleotides for "in vitro" DNA identification.
Starting Page	235
Ending Page	238
File Size	3270796
Page Count	4
File Format	PDF
ISBN	0780392140
DOI	10.1109/SMICND.2005.1558756
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-10-03
Publisher Place	Romania
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Silicon DNA Inductors Biological materials Testing Polymers Molecular biophysics Resistance heating Temperature Optical materials
Content Type	Text
Resource Type	Article

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