NDLI: New synchronized therapy with plasmapheresis and high-dose cyclophosphamide in severe systemic lupus erythematosus

Content Provider	IEEE Xplore Digital Library
Author	Demin, A. Sentjakova, T.
Copyright Year	2004
Description	Author affiliation: Dept. of Internal Medicine & Clinical Pharmacology, Novosibirsk State Medical Acad., Russia (Demin, A.; Sentjakova, T.)
Abstract	The aim of this study was to compare the outcomes of plasmapheresis (PP) in patients with severe lupus treated with cyclophosphamide (Cyc) boluses. The study analysis involved 30 patients. In group I, 15 patients were treated with synchronized therapy (PP, 60 ml/kg, followed by pulse Cyc, 750 mg/m/sup 2/, repeated monthly for 6 months), whereas in group II, 15 patients were given only intermittent Cyc boluses (at the same dosage). Patients were followed-up for a mean of 5 years. At the end of the 6-month treatment period, a statistically significant number patients in group I (80%) was in complete remission in comparison to group II (40%) (P< 0.02), whereas at long-term follow-up, these percentages were similar {40% vs. 53%, P = n.s.). The main functional and immunological parameters showed a normalization in both groups. We documented a higher rate of infectious complications in group I. This study reports that synchronized therapy is useful in inducing a faster remission in patients with severe lupus. However, it is not superior to conventional therapy at long-term follow-up analysis. Positive results should be reinforced by long-term maintenance therapy.
Starting Page	331
Ending Page	335
File Size	1093957
Page Count	5
File Format	PDF
ISBN	0780383834
DOI	10.1109/KORUS.2004.1555776
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2004-06-26
Publisher Place	Russia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Medical treatment Plasma measurements Cardiac disease Cardiovascular diseases Immune system Plasma applications Proteins Pulse measurements Cardiology Production
Content Type	Text
Resource Type	Article

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