NDLI: Influence of growth factor on internalization pathway of quantum dots into cells: PDGF effects internalization of QDs

Content Provider	IEEE Xplore Digital Library
Author	Damalakiene, L. Bagdonas, S. Rotomskis, R. Karabanovas, V. Ger, M. Valms, M.
Copyright Year	2009
Description	Author affiliation: Department of Developmental Biology Institute of Biochemistry, Vilnius, Lithuania (Ger, M.; Valms, M.) \|\| Biophotonics group of Quantum Electronic Department, Physics Faculty, Vilnius University, Vilnius, Lithuania (Damalakiene, L.; Bagdonas, S.; Rotomskis, R.) \|\| Laboratory of biomedical physics Institute of Oncology of Vilnius University, Vilnius, Lithuania (Karabanovas, V.)
Abstract	Tbe development of high-sensitivity and specificity probes that lack the intrinsic limitation of organic fluorescent dyes and sensitizers is of considerable interest in many areas of research, from cellular biology to molecular imaging and diagnostics. Quantum dots (QDs) are stable, bright fluorophores that can give high quantum yields, narrow emission bands, intense absorbance, very large Stokes shifts, high photostability and provide several emission colours under single excitation wavelength. In cell studies QD were observed to end up eventually in intracellular vesicles that could be identified in some cases as endosomes or lysosomes by organelle-speciflc labelling, or in a perinuclear region compatible with endosomal/lysosomal localisation. Real time and long term observations revealed that translation of these vesicles was possible in some cases, however the pathways of internalization and intracellular transport of QD in cells is still dim Accumulation of quantum dots, cells, vesicles, multi-vesicular body, growth factor PDGF-BB, confocal fluorescence microscopy
Starting Page	465
Ending Page	468
File Size	1007739
Page Count	4
File Format	PDF
ISBN	9781424448326
ISSN	19449380
e-ISBN	9789810836948
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2009-07-26
Publisher Place	Italy
Access Restriction	Subscribed
Rights Holder	Carmelina Ruggiero
Subject Keyword	Quantum dots Nanotechnology Council
Content Type	Text
Resource Type	Article

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