NDLI: High-Performance Interaction-Based Simulation of Gut Immunopathologies with ENteric Immunity Simulator (ENISI)

Content Provider	IEEE Xplore Digital Library
Author	Bisset, K. Alam, M.M. Bassaganya-Riera, J. Carbo, A. Eubank, S. Hontecillas, R. Hoops, S. Yongguo Mei Wendelsdorf, K. Dawen Xie Jae-Seung Yeom Marathe, M.V.
Copyright Year	2012
Abstract	Here we present the ENteric Immunity Simulator (ENISI), a modeling system for the inflammatory and regulatory immune pathways triggered by microbe-immune cell interactions in the gut. With ENISI, immunologists and infectious disease experts can test and generate hypotheses for enteric disease pathology and propose interventions through experimental infection of an in silico gut. ENISI is an agent based simulator, in which individual cells move through the simulated tissues, and engage in context-dependent interactions with the other cells with which they are in contact. The scale of ENISI is unprecedented in this domain, with the ability to simulate $10^7$ cells for 250 simulated days on 576 cores in one and a half hours, with the potential to scale to even larger hardware and problem sizes. In this paper we describe the ENISI simulator for modeling mucosal immune responses to gastrointestinal pathogens. We then demonstrate the utility of ENISI by recreating an experimental infection of a mouse with Helicobacter pylori 26695. The results identify specific processes by which bacterial virulence factors do and do not contribute to pathogenesis associated with H. pylori strain 26695. These modeling results inform general intervention strategies by indicating immunomodulatory mechanisms such as those used in inflammatory bowel disease may be more appropriate therapeutically than directly targeting specific microbial populations through vaccination or by using antimicrobials.
Starting Page	48
Ending Page	59
File Size	1018471
Page Count	12
File Format	PDF
ISBN	9781467309752
ISSN	15302075
DOI	10.1109/IPDPS.2012.15
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2012-05-21
Publisher Place	China
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Immune system Microorganisms Automata Mathematical model Biological system modeling Diseases Scalability BioComputing Computational Immunology Parallel Efficiency and Scalability Agent Based Simulation
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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