NDLI: Transdermal drug delivery with photomechanical waves

Content Provider	IEEE Xplore Digital Library
Author	Doukas, A. Shun Lee
Copyright Year	1999
Description	Author affiliation: Dept. of Dermatology, Massachusetts Gen. Hosp., Boston, MA, USA (Doukas, A.)
Abstract	Photomechanical waves (PWs) have been shown to permeabilize the stratum corneum (SC) in vivo and facilitate the transport of macromolecules into the viable epidermis and dermis. Furthermore, the barrier function of the stratum corneum recovers. Application of these waves to human volunteers has established that they do not cause any pain or discomfort and do not damage or change the appearance of the skin. These attributes of PWs make them potentially useful for transdermal drug delivery. The advantage of topical drug delivery is that it enhances the therapeutic effect of the drug while minimizing systemic side effects as well as reducing systemic deactivation or degradation of the drug. There are four important issues that need to be studied in order to determine the efficacy of photomechanical waves as a method for transdermal drug delivery. They are: 1. Penetration depth of the drug; 2. Molecular size that can be delivered through the SC; 3. Dosimetry, the amount of the drug that can be delivered into the epidermis and dermis; and 4. The mechanism(s) of the SC permeabilization. We have some partial answers to these questions.
Starting Page	360
Ending Page	361
File Size	145250
Page Count	2
File Format	PDF
ISBN	0780356349
ISSN	10928081
DOI	10.1109/LEOS.1999.813632
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	1999-11-08
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Drug delivery Dermis Laser ablation Probes Epidermis Laser mode locking Insulin Sugar Optical pulse generation Skin
Content Type	Text
Resource Type	Article
Subject	Electronic, Optical and Magnetic Materials Electrical and Electronic Engineering

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