NDLI: Glucose Oxidase (GOD)-Coupled Amperometric Microsensor with Integrated Electrochemical Actuation System

Content Provider	IEEE Xplore Digital Library
Author	Park, J. Kim, C. Zhang, S. Choi, M.
Copyright Year	2004
Description	Author affiliation: Missouri Univ., Rolla, MO (Park, J.; Kim, C.; Zhang, S.; Choi, M.)
Abstract	Recent developments for biosensors have been mainly focused on miniaturization and exploratory use of new materials. It should be emphasized that the absence of a novel "in-situ self-calibration/diagnosis technique" that is not connected to an external apparatus is a key obstacle to the realization of a biosensor for continuous use with minimum attendance. In order to address this issue, a novel solid-state glucose oxidase-coupled amperometric biosensor with integrated electrochemical actuation system has been designed and validated. There are two key components of the proposed glucose biosensor: solid-state GOD-coupled thin-1m amperometric sensing element and $O_{2}$ depleting/saturating built-in electrochemical actuator. The actuator can be used to accomplish in-situ 1-point self-calibration by depleting $O_{2}$ (i.e., by simulating glucose-free environment). Also, it can be used at the same time to extend the proposed sensor's linear detection range by increasing $O_{2}$ (i.e., by enhancing glucose sensitivity). A prototype sensor was fabricated and a series of lab experiments was conducted. Collected data assures that the proposed sensor effectively establishes the zero calibration point and significantly enhances its measurement sensitivity and confidence
Starting Page	134
Ending Page	138
File Size	138993
Page Count	5
File Format	PDF
ISBN	0780388798
DOI	10.1109/IMTC.2005.1604085
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2005-05-16
Publisher Place	Canada
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Sugar Microsensors Biosensors Electrodes Actuators Amperometric sensors Solid state circuits Thin film sensors Prototypes Calibration Glucose measurement Solid-state biosensor thin-lm amperometric sensor GOD(Glucose oxidase) Actuator
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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