NDLI: Stochastic simulation of a single gene cell model

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Stochastic simulation of a single gene cell model

Content Provider	IEEE Xplore Digital Library
Author	Kurtanjek, Z.
Copyright Year	2003
Description	Author affiliation: Fac. of Food Technol. and Biotechnol., Zagreb Univ., Croatia (Kurtanjek, Z.)
Abstract	A generic single gene cell model as an extension of a "standard" single enzyme (Monod) model is proposed. The model is structured at three levels: 1) gene transcription, 2) enzyme synthesis, and 3) metabolite and protein production. It accounts for a limiting substrate consumption, metabolite and biomass component production, gene transcription and enzyme synthesis. Control interactions between the key components at each level based on catalytic effects are assumed. Induction of gene transcription and enzyme synthesis as a cell response to step change of extracellular medium composition is simulated. In view of the small number of key molecules stochastic simulation is applied.
Sponsorship	Int. Assoc. Math. & Comput. Simulation: IEEE et al
Starting Page	489
Ending Page	493
File Size	313180
Page Count	5
File Format	PDF
ISBN	9539676967
ISSN	13301012
DOI	10.1109/ITI.2003.1225391
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2003-06-19
Publisher Place	Croatia
Access Restriction	Subscribed
Rights Holder	SRCE University Computing Centre
Subject Keyword	Stochastic processes Biochemistry Production Biomass Kinetic theory Inductors Computer simulation Chemical reactors Food technology Biotechnology
Content Type	Text
Resource Type	Article

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