NDLI: Detection and quantification of pathogenic bacteria using giant magnetic resistance sensor

Content Provider	IEEE Xplore Digital Library
Author	Bharath, S. Sam, A.R. Kalaivani, K.
Copyright Year	2015
Description	Author affiliation: Dept. of Electron. & Instrum. Eng., Easwari Eng. Coll., Chennai, India (Bharath, S.; Kalaivani, K.) \|\| CSIO, Chennai, India (Sam, A.R.)
Abstract	Clinical diagnosis of bacteria is very important. Currently there are many methods like ELISA (Enzyme Linked Immunosorbent Assay), PCR based method (Polymerase Chain Reaction), optical method and various other methods used for detecting the bacteria. ELISA and PCR based method takes more time for producing the results. The optical method suffers from the high background noise caused by stray light. Thus there is need for developing a device that is cheap and more sensitive. The magnetic sensing device is the best candidate to meet this criterion. Giant magnetic resistance (GMR) sensor is cheap, small and sensitive when compared to the other available magnetic sensors. Here the bacteria are tagged with $Fe_{2}O_{3}$ magnetic nano particles of size 40nm coated with suitable antibody. When external magnetic field is applied to the magnetic nano particles it will produce a local magnetic field and this magnetic field will cause change in the resistance of the GMR sensor. Thus by detecting the quantity of magnetic field produced by the magnetic nano particles the amount of bacteria in the sample can be quantified. The aim of the paper is to design a cost effective device that can sense the bacteria in the sample. Here the experimental setup has been designed and tested with different functionalized magnetic nano particles immobilized on the GMR sensing surface and applying the magnetic field in the z-axis direction.
Starting Page	160
Ending Page	164
File Size	741203
Page Count	5
File Format	PDF
e-ISBN	9781479977581
DOI	10.1109/TIAR.2015.7358550
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2015-07-10
Publisher Place	India
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Antigen Microorganisms Antibody Magnetic hysteresis Giant magnetic sensor Magnetic fields Nanobioscience Magnetic nano particles Perpendicular magnetic anisotropy Immune system
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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