NDLI: Integrated system to produce nano/microparticles for drug delivery using LTCC microfluidics devices

Content Provider	IEEE Xplore Digital Library
Author	Rincon Ardila, L.K. Gongora-Rubio, M.R. Wasnievski da Silva Ramos, L. Marim de Oliveira, A. Santana Balogh, T. Araujo Feitosa, V. Neto Pereira Cerize, N. Cobas Gomez, H.
Copyright Year	2014
Description	Author affiliation: Bionanomanufacture, Inst. for Technol. Res. of State of Sao Paulo, Sao Paulo, Brazil (Rincon Ardila, L.K.; Gongora-Rubio, M.R.; Wasnievski da Silva Ramos, L.; Marim de Oliveira, A.; Santana Balogh, T.; Araujo Feitosa, V.; Neto Pereira Cerize, N.) \|\| Lab. of Integrated Syst., Univ. of Sao Paulo, Sao Paulo, Brazil (Cobas Gomez, H.)
Abstract	Encapsulated nano/micro particles are highly used for biological, chemical, pharmaceutical and medical applications. The polymeric particles show potential capacity to release drugs and compatibility in biological environments. The emulsion/diffusion process is applied to produce these particles, and technologies based on microfluidic provide miniaturization of such process allowing particles with physical and chemical controlled characteristics. Nevertheless, the integrated system of technological devices like sensors, microactuators and controllers is crucial to improve the performance and efficiency of particles production with automatic cycles. The proposal of this work is to develop the integrated system to produce nano/microparticles for drug encapsulation, using microfluidics devices with control and automatic actions in continuous scale. The system is developed through devices integration, system characterization and control loops, using sensors, pumps, microfluidics devices, communication drivers, data acquisition, and control programs. The result of this work is the integrated system to produce particles of size 499-1500 nm with polydispersity index of 0.3 to 0.5 with potential to be used as drug delivery systems. The experimental results were validated by size measurement and polydispersity distribution with optical microscopy, scanning electron microscopy and dynamic light scattering.
Starting Page	1
Ending Page	4
File Size	1029935
Page Count	4
File Format	PDF
e-ISBN	9781479968367
DOI	10.1109/IBERSENSOR.2014.6995548
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2014-10-15
Publisher Place	Colombia
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Fabrication Drugs Automatic Control Microfluidic Devices Nano and Microparticles Pumps Integrated System Nanobioscience Polymers Drug Delivery Microfluidics Mixers
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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