NDLI: Regeneration following traumatic brain injury: Signals, signposts and scaffolds

Content Provider	IEEE Xplore Digital Library
Author	Beckerman, M.
Copyright Year	2010
Description	Author affiliation: Y12 National Security Complex, Oak Ridge, TN 37831 USA (Beckerman, M.) In this paper, we present a conceptual model of the steps to be taken in nerve regeneration. Starting with early vision we identify the key developmental steps leading to formation functional circuits. We then examine the two main approaches to nerve regeneration — the first centered on activating intrinsic growth restorative functions to injured axons and the second on stem cell based therapies. Guided by the findings in the visual system we propose the early application of patterned electrical stimulation. This has been shown to activate essential signaling pathways, ensure a balance between excitation and inhibition, establish reliable network topography, and provide a supportive framework for experience-driven, electrical activity during the highly plastic critical period. These steps should enhance the effectiveness during a corresponding critical period for motor system rehabilitation and nerve regeneration.
Starting Page	1
Ending Page	4
File Size	229100
Page Count	4
File Format	PDF
ISBN	9781424467136
e-ISBN	9781424467143
DOI	10.1109/BSEC.2010.5510841
Language	English
Publisher	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Publisher Date	2010-05-25
Publisher Place	USA
Access Restriction	Subscribed
Rights Holder	Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subject Keyword	Nerve fibers Visual system Signal restoration Circuits Medical treatment Stem cells Electrical stimulation Surfaces Plastics Brain injuries
Content Type	Text
Resource Type	Article

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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